Determination of Intrinsic Dissolution Rate Using Miniaturized Rotating and Stationary Disk Systems
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چکیده
منابع مشابه
Determination of Intrinsic Dissolution Rate Using Miniaturized Rotating and Stationary Disk Systems
The objective of this study was to assess the feasibility and reliability of using miniaturized disk dissolution apparatus for intrinsic dissolution rate (IDR) measurement in the early drug discovery process when bulk drug supply is very limited. The two apparatus, a miniaturized rotating disk system (mRDS) and a miniaturized stationary disk system (mSDS), were evaluated using chloramphenicol a...
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A correlation of the logarithmic values of the in vitro dissolution rate, G, and the apparent solubility, S, was evaluated in phosphate and ammonium acetate buffer at an initial pH of 7. The dissolution rates were determined with a newly designed and build miniaturized rotating disk equipment, as well as with a traditional rotating disk apparatus. The two apparatuses gave the same correlation p...
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ژورنال
عنوان ژورنال: Dissolution Technologies
سال: 2014
ISSN: 1521-298X
DOI: 10.14227/dt210214p24